Pair Name	Quercetin, Anti-PD-1 antibody
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Reshaped-->Tumor immune microenvironment
Gene Regulation	Up-regulation	Expression	ARG1	hsa383
	Up-regulation	Expression	CD4	hsa920
	Up-regulation	Expression	CD8A	hsa925
	Up-regulation	Expression	IFNG	hsa3458
	Up-regulation	Expression	IL10	hsa3586
	Down-regulation	Expression	IL12A	hsa3592
	Down-regulation	Expression	IL1B	hsa3553
	Down-regulation	Expression	IL4	hsa3565
	Down-regulation	Expression	IL6	hsa3569
	Up-regulation	Expression	ITGAM	hsa3684
	Up-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	NFKBIA	hsa4792
	Down-regulation	Expression	RELA	hsa5970
	Up-regulation	Expression	TGFB1	hsa7040
	Down-regulation	Expression	TLR4	hsa7099
	Down-regulation	Expression	TNF	hsa7124
In Vivo Model	Orthotopically transplanted HCC tumors in mice were treated with quercetin, anti-PD-1 antibody, or a combination of both therapies.
Result	Quercetin/anti-PD-1 antibody combination therapy reshaped HCC tumor microenvironment in mice in parallel with regulating the GM and macrophage immunity.